Fliban 100

Description

Fliban 100 (Flibanserin) – 100 mg Tablets

Manufacturer: Centurion Laboratories
Active Substance: Flibanserin
Strength: 100 mg per tablet
Pack Size: 4 tablets

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Product Description

Fliban 100 contains flibanserin, a non-hormonal, centrally acting pharmaceutical agent indicated for the treatment of hypoactive sexual desire disorder (HSDD) in women under 65 years of age. HSDD is characterized by persistently low sexual desire that causes marked distress or interpersonal difficulty and is not attributable to a coexisting medical or psychiatric condition, relationship problems, or the effects of medications or other substances.

Flibanserin was initially developed as an antidepressant and was later repurposed for female sexual dysfunction. It received initial U.S. Food and Drug Administration (FDA) approval in 2015 for premenopausal women, with an expanded indication for postmenopausal women under 65 granted in December 2025. Flibanserin is the first FDA-approved medication for female sexual dysfunction.

The mechanism of action involves selective modulation of serotonin receptors in the central nervous system. Flibanserin acts as an agonist at 5-HT1A receptors and an antagonist at 5-HT2A receptors. This pharmacodynamic profile is believed to reduce serotonin activity while increasing norepinephrine and dopamine levels in the prefrontal cortex. These neurotransmitter changes are thought to enhance sexual desire and arousal.

Clinical efficacy has been established in randomized, double-blind, placebo-controlled trials. In the pivotal SNOWDROP trial involving postmenopausal women, flibanserin 100 mg administered at bedtime demonstrated statistically significant improvements in the number of satisfying sexual events and in the desire domain of the Female Sexual Function Index compared with placebo. The treatment also showed a greater reduction in distress related to low sexual desire. More than 3,200 women participated in clinical studies, including 902 postmenopausal women under 65.

The recommended dosage is one 100 mg tablet taken orally once daily at bedtime. Bedtime administration is critical because taking flibanserin during waking hours significantly increases the risks of hypotension, syncope, accidental injury, and central nervous system depression including somnolence and sedation. If no improvement in symptoms is observed after 8 weeks of treatment, discontinuation should be considered.

Flibanserin is contraindicated in patients with hepatic impairment due to substantially increased drug exposure and risk of severe hypotension and syncope. It is also contraindicated with moderate or strong CYP3A4 inhibitors and in individuals with known hypersensitivity to flibanserin or any of its components.

Common adverse reactions reported at an incidence of 2% or greater include dizziness, somnolence, nausea, fatigue, insomnia, urinary tract infection, anxiety, sinusitis, constipation, and dry mouth.

Fliban 100 is supplied by Centurion Laboratories in a pack of 4 film-coated tablets, each containing 100 mg of flibanserin.

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Important Safety Information

Flibanserin carries a boxed warning regarding hypotension and syncope. Use of flibanserin and alcohol together close in time increases the risk of severe hypotension and syncope. Patients must wait at least two hours after consuming one or two standard alcoholic drinks before taking flibanserin at bedtime. If three or more alcoholic drinks have been consumed that evening, the flibanserin dose must be skipped. After taking flibanserin at bedtime, alcohol should be avoided until the following day.

Patients should avoid activities requiring full alertness, such as driving or operating machinery, until at least six hours after each dose and until they understand how flibanserin affects them.

Flibanserin is not indicated for use in men and should not be used to enhance sexual performance. It is not recommended for use in the elderly, and safety and efficacy have not been established in this population.

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Top 10 Frequently Asked Questions

1. What is Fliban 100 used for?

Fliban 100 contains flibanserin, which is indicated for the treatment of hypoactive sexual desire disorder (HSDD) in women under 65 years of age. HSDD is defined as low sexual desire that causes marked distress or interpersonal difficulty and is not caused by a medical or psychiatric condition, relationship problems, or the effects of medications.

2. How does flibanserin work?

Flibanserin modulates serotonin receptors in the brain. It acts as an agonist at 5-HT1A receptors and an antagonist at 5-HT2A receptors. This activity is believed to reduce serotonin levels while increasing dopamine and norepinephrine, neurotransmitters associated with sexual desire and arousal.

3. What is the recommended dosage of Fliban 100?

The recommended dosage is one 100 mg tablet taken orally once daily at bedtime. Bedtime administration is essential to minimise the risk of hypotension, fainting, and sedation.

4. What are the common side effects of flibanserin?

Common adverse reactions occurring in 2% or more of patients include dizziness, somnolence, nausea, fatigue, insomnia, urinary tract infection, anxiety, sinusitis, constipation, and dry mouth.

5. Can I drink alcohol while taking Fliban 100?

Alcohol consumption close in time to flibanserin dosing significantly increases the risk of severe hypotension and syncope. You must wait at least two hours after consuming one or two alcoholic drinks before taking your bedtime dose. If you have consumed three or more alcoholic drinks that evening, skip your dose. After taking flibanserin, avoid alcohol until the next day.

6. Who should not take flibanserin?

Flibanserin is contraindicated in patients with hepatic impairment, those taking moderate or strong CYP3A4 inhibitors, and individuals with known hypersensitivity to flibanserin or any tablet components. It is not indicated for men and should not be used to enhance sexual performance. It is not recommended for elderly patients.

7. How long does it take for flibanserin to work?

If no improvement in symptoms is observed after 8 weeks of treatment, flibanserin should be discontinued. Clinical studies assessed efficacy over 24-week periods.

8. Can I take flibanserin with other medications?

Flibanserin interacts with many medications. Moderate or strong CYP3A4 inhibitors are contraindicated due to increased flibanserin concentrations and risk of severe hypotension. Oral contraceptives and other weak CYP3A4 inhibitors can increase flibanserin exposure. Always inform your healthcare provider about all medications, including nonprescription products and herbal supplements such as St. John’s wort, cimetidine, and omeprazole.

9. What should I do if I experience dizziness or fainting?

If you experience lightheadedness, dizziness, or fainting, lie down immediately and contact your doctor promptly. These symptoms may indicate hypotension, which is a known risk with flibanserin.

10. Is flibanserin FDA-approved?

Yes, flibanserin (brand name Addyi) received initial FDA approval in 2015 for premenopausal women. In December 2025, the FDA expanded approval to include postmenopausal women under 65 years of age.

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References and Reputable Sources

• FDA Approved Prescribing Information (Addyi): https://addyi.com/pi/

• DailyMed – NIH National Library of Medicine: https://dailymed.nlm.nih.gov

• MedlinePlus – Flibanserin: https://medlineplus.gov/druginfo/meds/a615040.html

• Mayo Clinic – Flibanserin (Oral Route): https://www.mayoclinic.org

• Clinical Trial Registry (SNOWDROP): NCT00996372

• FDA Drug Safety Information: https://www.fda.gov/Drugs/DrugSafety