Description

Duralast 30 mg Tablets – Dapoxetine for Premature Ejaculation

Manufacturer: Sun Pharmaceutical Industries Ltd.
Active Substance: Dapoxetine (30 mg per tablet)
Pack Size: 4 tablets per strip

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Product Description

Duralast 30 mg tablets contain dapoxetine, a selective serotonin reuptake inhibitor (SSRI) specifically developed for the on-demand treatment of premature ejaculation (PE) in adult men aged 18 to 64 years.Premature ejaculation is a common male sexual dysfunction characterized by persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration, and before the individual desires, leading to marked personal distress or interpersonal difficulty.

Dapoxetine, the active ingredient in Duralast, works by inhibiting the neuronal reuptake of serotonin, thereby increasing serotonin concentrations in the synaptic cleft and potentiating the neurotransmitter’s action at pre- and post-synaptic receptors.This mechanism prolongs the intravaginal ejaculatory latency time (IELT) and improves ejaculatory control, allowing for more satisfying and prolonged sexual experiences.

Clinical studies have demonstrated that dapoxetine 30 mg taken on-demand significantly increases IELT, with trials showing a 197% median gain in ejaculation time compared to baseline.The medication is designed to be taken only when sexual activity is anticipated, providing flexibility and convenience for users.

Duralast 30 mg is manufactured by Sun Pharmaceutical Industries Ltd., one of the world’s largest pharmaceutical companies, ensuring high-quality standards and reliable production.

Duralast 30 mg is indicated for men who experience:

• Intravaginal ejaculatory latency time of less than two minutes

• Persistent or recurrent ejaculation with minimal sexual stimulation

• Marked personal distress or interpersonal difficulty as a consequence of PE

• Poor control over ejaculation

• A history of premature ejaculation in the majority of intercourse attempts over the prior 6 months

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Dosage and Administration

The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to anticipated sexual activity.The tablet should be swallowed whole with at least one full glass of water.

Important dosage guidelines:

• Do not take more than one tablet within 24 hours

• Duralast is not intended for continuous daily use

• Treatment should not be initiated with the 60 mg dose

• If response to 30 mg is insufficient and no moderate or severe adverse reactions have occurred, the dose may be increased to 60 mg

• A careful benefit-risk assessment should be performed after the first four weeks of treatment (or after at least six doses)

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Side Effects

As with all medications, Duralast 30 mg may cause side effects. The most common adverse effects include:

• Nausea

• Dizziness or light-headedness

• Headache

• Dry mouth

• Diarrhea

• Insomnia

• Fatigue

Less common but more serious side effects may include fainting (syncope), orthostatic hypotension, anxiety, agitation, restlessness, and blurred vision.Patients should rise slowly from a sitting or lying position to minimize the risk of dizziness or fainting.

If you experience any severe side effects or symptoms such as swelling of the face, eyes, lips, or tongue, difficulty breathing, or itchy skin rashes, seek medical attention immediately.

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Contraindications and Precautions

Duralast 30 mg should not be used in the following cases:

• Known hypersensitivity to dapoxetine or any tablet components

• Concurrent use with other SSRIs, MAOIs, or other serotonergic medications

• Use within 14 days of discontinuing treatment with MAOIs or other serotonergic products

• Severe liver impairment (Child-Pugh score 7-15)

• Severe renal impairment

• History of mania, bipolar disorder, or severe depression

• Certain cardiovascular conditions, including heart failure or ischemic heart disease

• Epilepsy or seizure disorders

• Glaucoma or elevated intraocular pressure

Caution is advised in patients with mild to moderate renal impairment, orthostatic hypotension, cardiovascular disease, and those taking CYP3A4 or CYP2D6 inhibitors.

Duralast is not recommended for use in patients under 18 years of age or over 65 years of age, as efficacy and safety have not been established in these populations.

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Drug Interactions

Dapoxetine may interact with various medications. Patients should inform their healthcare provider about all medications they are taking, including:

• Other SSRIs or SNRIs

• Monoamine oxidase inhibitors (MAOIs)

• Serotonergic medications or herbal products (e.g., St. John’s Wort)

• PDE5 inhibitors (e.g., sildenafil) – concurrent use may lower blood pressure

• CYP3A4 and CYP2D6 inhibitors

• Alcohol – may increase the risk of neurocognitive effects and syncope

• Grapefruit juice – should be avoided at least 24 hours before dosing

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Frequently Asked Questions

1. What is Duralast 30 mg used for?

Duralast 30 mg is used to treat premature ejaculation (PE) in adult men aged 18 to 64 years. It increases the time taken to ejaculate and improves control over ejaculation, reducing frustration and worry associated with PE.

2. How does Duralast 30 mg work?

Duralast 30 mg contains dapoxetine, a selective serotonin reuptake inhibitor (SSRI). It works by inhibiting the reuptake of serotonin in the nervous system, increasing serotonin levels between nerve cells. This potentiates serotonin’s action and delays ejaculation.

3. How should I take Duralast 30 mg?

Take one 30 mg tablet with a full glass of water approximately 1 to 3 hours before anticipated sexual activity. Do not take more than one tablet within 24 hours. The tablet should be swallowed whole and not chewed, crushed, or broken.

4. Is Duralast 30 mg safe?

Duralast 30 mg is safe when used at the prescribed dose and duration as advised by a healthcare professional. However, like all medications, it may cause side effects. Common side effects include nausea, dizziness, headache, and dry mouth.

5. Can Duralast 30 mg cure premature ejaculation?

Duralast 30 mg is an effective treatment for premature ejaculation when used on-demand. It significantly improves ejaculatory control and increases IELT. However, it is not a permanent cure; it is taken as needed before sexual activity to manage the condition.

6. Do I need a prescription for Duralast 30 mg?

Yes, Duralast 30 mg is a prescription medication and should only be used under the guidance of a qualified healthcare professional.

7. Can I take Duralast 30 mg with alcohol?

No, alcohol should be avoided while taking Duralast 30 mg. Alcohol may increase the risk of neurocognitive effects and syncope (fainting).

8. Can Duralast 30 mg cause erectile dysfunction?

Duralast 30 mg may cause erectile dysfunction (difficulty in getting or maintaining an erection) in some patients. If you experience this side effect, consult your doctor.

9. Can I take Duralast 30 mg with sildenafil (Viagra)?

Taking Duralast 30 mg with sildenafil may lower blood pressure, particularly upon standing. Consult your doctor before taking these medications together.

10. Is Duralast 30 mg FDA approved?

Dapoxetine is not approved by the US Food and Drug Administration (FDA). However, it is approved in many other countries, including those in the European Union, for the treatment of premature ejaculation.

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Clinical Evidence and Guidelines

Clinical guidelines from the British Society for Sexual Medicine (BSSM) recommend on-demand dapoxetine as a first-line licensed treatment for premature ejaculation.A randomized clinical trial published in 2025 demonstrated that dapoxetine 30 mg on-demand resulted in significant improvements in IELT, with a 197% median gain from baseline.The European Medicines Agency (EMA) has confirmed that the benefits of dapoxetine outweigh its risks when used as indicated.

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References

• European Medicines Agency (EMA) – Priligy referral: https://www.ema.europa.eu/en/medicines/human/referrals/priligy【12】

• NCATS Inxight Drugs – Dapoxetine: https://drugs.ncats.io/drug/GB2433A4M3【11】

• PubMed Central – Clinical trial on dapoxetine efficacy: https://pmc.ncbi.nlm.nih.gov/articles/PMC12667069/【13】

• Patient.info – Dapoxetine tablets information: https://fr.patient.info/medicine/dapoxetine-tablets-priligy【14】

• Farmacotherapeutisch Kompas – Dapoxetine dosage guidelines: https://www.farmacotherapeutischkompas.nl/bladeren/preparaatteksten/d/dapoxetine【15】

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Disclaimer: This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any medication. Duralast 30 mg should only be used under the supervision of a licensed physician.

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