Description

Mesterolone (Proviron) 25mg by ZPHC

Product Type: Oral Anabolic Androgenic Steroid

Active Ingredient: Mesterolone

Concentration: 25 mg per tablet

Volume: Pack of 100 tablets

Manufacturer: ZPHC

Product Description

Mesterolone 25mg ZPHC, commonly known as Proviron, is an oral androgenic medication containing the active substance mesterolone. The 25mg tablet formulation from ZPHC is designed for individuals requiring androgen therapy under professional medical supervision.

The active ingredient mesterolone has a chemical formula of C20H32O2 and demonstrates a distinct pharmacological profile with an anabolic activity index of 40-50 and an androgenic activity index of 150-200. This product is manufactured to strict quality standards and is available for domestic delivery within the United States.

Mechanism of Action

Mesterolone functions as an androgen receptor agonist, increasing the activity of androgens in the body. According to Bayer’s product information, mesterolone is rapidly absorbed following oral administration, with maximum serum drug levels of approximately 3.1 ng/mL achieved after 1.6 hours . The terminal half-life is 12 to 13 hours, and the substance is approximately 98% bound to serum proteins, with binding to sex hormone-binding globulin accounting for about 58% .

In the recommended therapeutic dosage, mesterolone does not impair spermatogenesis and is well tolerated by the liver . The absolute bioavailability of mesterolone is approximately 3% of the oral dose . Importantly, no metabolic conversion into estrogens or corticoids has been observed .

Indications for Use

Proviron is indicated for the treatment of conditions caused by deficient endogenous androgen formation in male patients . These conditions include:

• Disturbances due to androgen deficiency, including decreased physical activity, rapid fatigability, decreased memory and concentration, libido and potency disturbances, irritability, and depressive tendencies 

• Hypogonadism, for stimulating the growth, development, and function of androgen-dependent target organs and the development of secondary male sexual characteristics 

• Infertility, where mesterolone can increase sperm count and improve sperm quality by increasing and normalizing fructose concentration in the ejaculate 

Product Features

• Potency: 25 mg per tablet

• Presentation: 100 tablets per pack ensuring consistent and accurate dosing

• Formulation: Pure mesterolone in a stable oral tablet form

• Detection Time: Approximately 6 weeks, relevant for individuals subject to drug testing protocols

• Storage: Store below 30°C, protected from light, and keep out of reach of children 

Recommended Dosage

The following dosages are recommended based on the condition being treated :

• For disturbances due to androgen deficiency: Begin with 1 tablet three times daily. After satisfactory clinical improvement is achieved, a dose reduction may be attempted, with maintenance typically at 1 tablet once or twice daily 

• For hypogonadism: For development of secondary male sexual characteristics, 1-2 tablets three times daily for several months. Maintenance dose is typically 1 tablet 2-3 times daily 

• For infertility: 1 tablet 2-3 times daily for approximately 90 days (a complete spermatogenic cycle) 

Important: Dosages should always be determined by a qualified healthcare professional based on individual clinical assessment, and regular monitoring should be performed .

Side Effects

Potential side effects reported with mesterolone use include :

• Abdominal pain and gastrointestinal discomfort

• Acne

• Alopecia (hair loss)

• Headache

• Increased frequency of erections

• Priapism (prolonged and undesirable erections)

In individual cases where frequent or very prolonged erections occur, dose reduction or treatment discontinuation is recommended to avoid penile injury .

The following adverse effects have been reported for androgens in general :

• Fluid retention and impaired glucose tolerance

• Altered lipids and haematological parameters

• Abnormal liver function tests

• Gynaecomastia and prostate hyperplasia

• Virilization and hirsutism

• Psychiatric disturbances including aggression, depression, and emotional lability

Regular examinations of the prostate should be carried out as a precautionary measure during treatment .

Drug Interactions

Androgens have been reported to enhance the activity of certain drugs, with resulting increases in toxicity. Drugs affected include cyclosporin, antidiabetics, thyroxine, and anticoagulants such as warfarin . Resistance to the effects of neuromuscular blockers has also been reported .

Warnings

Drug Abuse and Dependency: Mesterolone has been abused, typically in combination with other anabolic-androgenic steroids. The abuse of mesterolone and other anabolic-androgenic steroids carries serious health risks, including cardiovascular events (with fatal outcomes in some cases), hepatic and/or psychiatric events, and dependency . The product is not suitable for muscle development in healthy men or for increasing physical ability .

Hepatic Considerations: In rare cases, benign and, in even rarer cases, malignant liver tumours leading in isolated cases to life-threatening intra-abdominal haemorrhage have been observed after the use of hormonal substances such as mesterolone . Patients with severe abdominal pain, hepatomegaly, or signs of intra-abdominal haemorrhage should be evaluated for the possibility of a liver tumour .

Lactose Content: Each Proviron 25mg tablet contains 60.050 mg of lactose monohydrate . Patients with rare hereditary conditions such as galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption must not use this medication .

Purchase Information

Mesterolone 25mg ZPHC is available for those seeking to enhance muscle hardness, improve libido, and support hormone balance. Ensure product authenticity and quality by purchasing through authorized channels. Delivery is prompt and reliable, with shipping times ranging from 2 to 5 days for USA domestic orders.

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Frequently Asked Questions (FAQs)

1. What is Mesterolone (Proviron) used for?

Mesterolone is indicated for the treatment of conditions caused by androgen deficiency in men, including decreased physical activity, rapid fatigability, libido and potency disturbances, hypogonadism, and infertility . It balances the deficiency of androgen formation which begins to decline with increasing age .

2. What is the recommended dosage for Mesterolone 25mg?

For androgen deficiency: 1 tablet three times daily initially, then maintenance at 1-2 tablets daily. For hypogonadism: 1-2 tablets three times daily for several months, then maintenance at 2-3 tablets daily. For infertility: 1 tablet 2-3 times daily for approximately 90 days . Dosages should be prescribed by a healthcare professional based on individual clinical assessment .

3. How long does it take for Mesterolone to work?

Mesterolone is rapidly absorbed after oral administration, with maximum serum drug levels achieved after approximately 1.6 hours . However, the clinical benefits for conditions such as infertility require treatment over a complete spermatogenic cycle, approximately 90 days . Continuous treatment over several months is generally recommended for most indications .

4. What are the potential side effects of taking Mesterolone?

Potential side effects include abdominal pain, acne, alopecia (hair loss), headache, increased frequency of erections, and priapism . Other adverse effects reported with androgens in general include fluid retention, impaired glucose tolerance, altered lipids, abnormal liver function tests, prostate hyperplasia, and psychiatric disturbances such as aggression and depression .

5. Is Mesterolone suitable for use in women?

No. Proviron is for use in male patients only and must not be taken by women . The product is contraindicated for use in females .

6. Can Mesterolone be used for bodybuilding or muscle enhancement?

No. The manufacturer specifically warns that Proviron is not suitable for bodybuilding, increasing muscles in healthy men, or for increasing physical ability . The abuse of mesterolone and other anabolic-androgenic steroids carries serious health risks including cardiovascular events, hepatic events, and dependency .

7. What health monitoring is recommended when taking Mesterolone?

Regular examinations of the prostate should be carried out as a precautionary measure . Liver function monitoring is also recommended . If unusual and long-term upper abdominal complaints occur, medical attention should be sought immediately as this could indicate a life-threatening intra-abdominal haemorrhage .

8. Does Mesterolone interact with other medications?

Yes. Androgens have been reported to enhance the activity of certain drugs, resulting in increased toxicity. Drugs affected include cyclosporin, antidiabetics, thyroxine, and anticoagulants such as warfarin . Resistance to the effects of neuromuscular blockers has also been reported. Always inform your healthcare provider about all medications you are taking .

9. What are the contraindications for Mesterolone use?

Mesterolone should not be used by individuals with prostate cancer, previous or existing liver tumours, hypersensitivity to mesterolone or any excipients, or by women . The product is also contraindicated in patients with hereditary conditions such as galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption .

10. How should Mesterolone be stored?

Store below 30°C in a cool, dry place, protected from light . Keep out of the reach and sight of children . Do not use after the expiry date, and do not dispose of medicines via wastewater or household waste—consult your pharmacist for proper disposal methods .

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