Description

SixPex Oxapex 25

Oxandrolone Tablets – 100 Tablets, 25 mg per Tablet

Product Overview

Oxandrolone is a synthetic anabolic-androgenic steroid derived from testosterone. Each tablet provides 25 mg of oxandrolone, with 100 tablets per package. Oxandrolone is recognized for its anabolic properties, which support tissue-building processes in the body, while exhibiting relatively weak androgenic activity compared to other compounds in its class.

Mechanism of Action

Oxandrolone works by binding to androgen receptors in target tissues, activating transcription factors that influence protein synthesis. This mechanism promotes nitrogen retention and increases the amount of protein produced by the body, which is utilised to build muscle tissue and support weight gain. During exogenous administration of anabolic androgens, endogenous testosterone release is inhibited through suppression of pituitary luteinizing hormone (LH). At larger doses, spermatogenesis may be suppressed through feedback inhibition of pituitary follicle-stimulating hormone (FSH).

Clinical Indications

Oxandrolone is indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma. It is also used to offset the protein catabolism associated with prolonged corticosteroid administration and for the relief of bone pain frequently accompanying osteoporosis. In patients who fail to gain or maintain normal weight without definite pathophysiologic reasons, oxandrolone may be prescribed as part of a comprehensive treatment plan.

Pharmacokinetic Profile

Pharmacokinetic studies demonstrate a mean elimination half-life of approximately 10.4 hours in younger volunteers and 13.3 hours in elderly subjects. No significant differences between younger and elderly populations have been found for time to peak concentration, peak plasma concentration, or area under the curve following a single dose.

Important Safety Information

Oxandrolone is classified as a Schedule III controlled substance under the Anabolic Steroids Control Act of 1990.

Contraindications

Oxandrolone is contraindicated in individuals with:

• Known or suspected carcinoma of the prostate or male breast

• Carcinoma of the breast in females with hypercalcemia

• Pregnancy – oxandrolone may cause masculinisation of the female fetus

• Nephrosis or the nephrotic phase of nephritis

• Hypercalcemia

Warnings and Precautions

Oxandrolone and similar medications may cause damage to the liver or spleen and liver tumours. Peliosis hepatis, a condition in which liver and sometimes splenic tissue is replaced with blood-filled cysts, has been reported in patients receiving androgenic anabolic steroid therapy. These cysts are sometimes present with minimal hepatic dysfunction but have been associated with liver failure. Withdrawal of the drug usually results in complete disappearance of lesions. Liver cell tumours have also been reported; most are benign and androgen-dependent, but fatal malignant tumours have been documented.

Oxandrolone may increase low-density lipoprotein (LDL or “bad cholesterol”) and decrease high-density lipoprotein (HDL or “good cholesterol”), which may increase the risk of developing heart disease or atherosclerosis. These levels typically revert to normal upon discontinuation of treatment.

Patients should seek immediate medical attention if they experience upset stomach, extreme tiredness, unusual bruising or bleeding, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms, pale or clammy skin, or nausea and vomiting.

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Top 10 Frequently Asked Questions

1. What is Oxandrolone used for?

Oxandrolone is used as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma. It is also indicated to offset protein catabolism associated with prolonged corticosteroid use and for relief of bone pain in osteoporosis.

2. How does Oxandrolone work in the body?

Oxandrolone works by binding to androgen receptors and activating transcription factors, which increases protein synthesis in the body. This leads to enhanced nitrogen retention and muscle tissue building.

3. What is the typical dosage of Oxandrolone?

Typical dosages vary based on individual needs and medical supervision. For medical use, oxandrolone is usually taken two to four times daily. Your healthcare provider will determine the appropriate dosage based on your specific condition.

4. What are the common side effects of Oxandrolone?

Common side effects include changes in cholesterol levels (increased LDL and decreased HDL), potential liver enzyme elevation, and suppression of endogenous testosterone production. More serious side effects include liver damage, peliosis hepatis, and liver tumours.

5. Is Oxandrolone safe for long-term use?

Long-term use of oxandrolone carries significant risks, including hepatotoxicity, cardiovascular effects, and hormonal imbalances. Medical supervision and regular monitoring of liver function and lipid profiles are essential during treatment.

6. Who should not take Oxandrolone?

Oxandrolone is contraindicated in individuals with prostate cancer, male breast cancer, breast cancer in females with hypercalcemia, pregnancy, nephrosis, or hypercalcemia.

7. Does Oxandrolone affect cholesterol levels?

Yes. Anabolic steroids, including oxandrolone, have been reported to increase low-density lipoproteins and decrease high-density lipoproteins. These levels typically return to normal upon discontinuation of treatment.

8. Can Oxandrolone be used by women?

Oxandrolone is contraindicated in pregnant women due to the risk of masculinisation of the female fetus. Women who are breastfeeding or planning to become pregnant should not use this medication. Virilisation effects may occur in women with prolonged use.

9. How should Oxandrolone be stored?

Oxandrolone tablets should be stored at room temperature, away from moisture and heat. Keep out of reach of children and follow all storage instructions provided with the product.

10. Is Oxandrolone a controlled substance?

Yes. Oxandrolone is classified as a Schedule III controlled substance under the Anabolic Steroids Control Act of 1990.

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References and Reputable Sources

• DailyMed – Oxandrolone Tablets, USP (NIH)

• MedlinePlus – Oxandrolone (NIH)

• FDA Label – Oxandrolone Tablets

• PubMed – Transdermal Oxandrolone Study

• Drugs.com – Oxandrolone Side Effects