Description

L-Glutathione ZPHC – 3000 mg Kit (5×600 mg Vials + Diluent)

Product Code: ZPHC-GSH-3000
Price: $59.00

Product Overview

The L-Glutathione ZPHC 3000 mg Kit is a pharmaceutical-grade research preparation containing reduced L-glutathione (GSH) in a sterile, lyophilized format. This comprehensive kit provides five 600 mg vials of high-purity glutathione tripeptide alongside a sterile diluent, delivering a total of 3000 mg of active compound for research applications. L-glutathione, composed of glutamic acid, cysteine, and glycine, serves as the primary endogenous antioxidant in mammalian cells and plays a central role in maintaining cellular redox homeostasis . The reduced form (GSH) is the physiologically active state that participates in neutralizing reactive oxygen species and supporting cellular detoxification processes .

Key Features

Pharmaceutical-Grade Quality
Each vial contains lyophilized reduced L-glutathione manufactured under stringent quality control standards. The product achieves ≥99% purity as verified by High-Performance Liquid Chromatography (HPLC), ensuring research-grade consistency for experimental protocols . Each unit features a scratch-code verification system for authenticity confirmation.

Comprehensive Kit Configuration
The kit includes five individually sealed 600 mg vials of lyophilized glutathione powder plus one sterile diluent ampoule for reconstitution. This multi-vial presentation supports flexible dosing schedules and reduces waste in research settings requiring repeat administrations.

Enhanced Stability Profile
Nitrogen overlay technology protects the vulnerable thiol group (-SH) from oxidation during storage and transport. This critical feature preserves the reduced state of glutathione, which is essential for its antioxidant and redox-regulating functions . The lyophilized formulation maintains stability when stored under refrigerated conditions.

Research-Ready Presentation
Tamper-evident caps and sterile packaging ensure product integrity. The multi-vial format accommodates both single-use and multi-use research protocols with minimal cross-contamination risk.

Technical Specifications

Research Applications

Oxidative Stress Modulation
Reduced glutathione serves as the principal intracellular antioxidant, directly scavenging reactive oxygen and nitrogen species while supporting enzymatic antioxidant systems . Research models investigating oxidative stress pathways frequently employ GSH to replenish intracellular antioxidant capacity and evaluate redox-sensitive signaling mechanisms. The 600-1200 mg dosage range is commonly utilized in oxidative stress modulation protocols.

Cellular Detoxification Studies
GSH functions as a cofactor for glutathione S-transferases and glutathione peroxidases, enzymes critical for xenobiotic detoxification and peroxide reduction . Research examining hepatic detoxification pathways, drug metabolism, and environmental toxicant effects regularly incorporates glutathione administration in experimental designs.

Redox Signaling Investigations
The reversible oxidation of GSH to glutathione disulfide (GSSG) and the maintenance of the GSH/GSSG ratio represent key parameters in redox signaling research . This kit enables precise manipulation of cellular redox status for studying signal transduction pathways, protein S-glutathionylation, and transcription factor regulation.

Protocol Flexibility
The included diluent allows for customizable concentration setups. Reconstitution protocols can accommodate both intravenous and intramuscular administration routes in research models . Synergistic pairing with vitamin C may enhance redox cycling and recycling efficiency in experimental protocols.

Quality Assurance

• Certified Reference Material (CRM) standard

• Sterility and endotoxin testing approved

• HPLC-verified purity ≥99%

• Nitrogen overlay for thiol group protection

• Scratch-code validation for authenticity

• Refrigerated storage recommended

• Tamper-evident packaging

Reconstitution Guidelines

Each 600 mg vial is designed for reconstitution with the provided sterile diluent. For research protocols requiring precise concentrations, the diluent volume can be adjusted according to experimental parameters. Standard reconstitution for injection research typically employs 4 mL of diluent per 600 mg vial, yielding a concentration suitable for further dilution or direct administration . Always inspect the reconstituted solution for clarity and particulate matter before use.

---

Top 10 Frequently Asked Questions

1. What is the difference between reduced and oxidized glutathione?
Reduced glutathione (GSH) contains a free thiol (-SH) group that enables it to act as an electron donor in antioxidant reactions. When GSH neutralizes reactive oxygen species, it becomes oxidized to glutathione disulfide (GSSG). The GSH/GSSG ratio is considered a key indicator of cellular redox status. This product contains the reduced form, which is the physiologically active state required for antioxidant function .

2. How should the lyophilized vials be stored?
The lyophilized vials should be stored under refrigerated conditions (2-8°C) to maintain stability. The nitrogen overlay protects the thiol group from oxidation during storage. Once reconstituted, the solution should be used immediately or according to research protocol requirements; do not store reconstituted solution for extended periods .

3. What is the purity level of this product?
This product achieves ≥99% purity as verified by High-Performance Liquid Chromatography (HPLC) testing. Each batch undergoes rigorous quality control testing to ensure consistency and reliability for research applications. The scratch-code verification system allows users to confirm authenticity .

4. Is the diluent included with the kit?
Yes, the kit includes one sterile diluent ampoule sufficient for reconstituting all five vials. The included diluent is specifically formulated for compatibility with the lyophilized glutathione, eliminating the need for separate procurement of sterile water or saline solutions.

5. What is the typical dosage range for research applications?
Research protocols commonly employ 600-1200 mg per administration for oxidative stress modulation models. Clinical literature references dosages of 300-600 mg daily for hepatic applications, with higher doses (1.5 g/m²) used in chemotherapy support protocols . Dosage selection should be determined by the specific research parameters and experimental design.

6. Can this product be combined with other antioxidants in research protocols?
Synergistic pairing with vitamin C is common in research protocols, as vitamin C can facilitate the recycling of oxidized glutathione back to its reduced form, potentially enhancing redox cycling efficiency. However, combination protocols should be validated for compatibility and stability before implementation.

7. What is the significance of the nitrogen overlay?
The nitrogen overlay protects the vulnerable thiol (-SH) group from oxidation during storage and transport. This group is essential for glutathione’s antioxidant function, as it is the site where electron transfer occurs during redox reactions. Maintaining the reduced state is critical for product efficacy in research applications .

8. How do I verify product authenticity?
Each vial features a scratch-code verification system. Users can scratch off the security label to reveal a unique code, then validate the code through the manufacturer’s verification system. This ensures the product is genuine and meets quality specifications.

9. What is the recommended reconstitution procedure?
For research purposes, dissolve 600 mg of lyophilized powder in 4 mL of the provided sterile diluent . The solution should be used promptly after reconstitution. For intravenous infusion research protocols, the reconstituted solution can be further diluted in physiological saline or glucose solution .

10. What conditions is this product indicated for in clinical research?
Clinical research has investigated glutathione for various applications including liver diseases (viral, drug-induced, and alcoholic), chemotherapy and radiation therapy support, hypoxic conditions, and detoxification support . It is also studied in cardiovascular disease models, neurodegenerative conditions, and aging-related oxidative stress research . All use should be strictly limited to research protocols.

---

References

1. Consentz Directory. Glutathione 600 mg Powder Vial (TAD) – Injectable antioxidant medicine for Aesthetic Clinics. 

2. Lutasun Product Information. Reduced Glutathione Formulations and Dosage. 

3. 39 Health Network. Reduced Glutathione Sodium for Injection (Gulading) Package Insert. 

4. 39 Health Network. Reduced Glutathione for Injection (Atuomolan) Package Insert. 

5. Lana JV, Rios A, Takeyama R, et al. Nebulized Glutathione as a Key Antioxidant for the Treatment of Oxidative Stress in Neurodegenerative Conditions. Nutrients. 2024;16(15):2476. 

6. Oxidative Medicine and Cellular Longevity. Glutathione in Cardiovascular Health and Disease. Wiley Online Library. 

7. Pompella A, Corti A. The changing faces of glutathione, a cellular protagonist. Frontiers Media SA. 

8. The Antioxidant Glutathione. ScienceDirect. 2023. 

9. Botanical Cube. L-Glutathione GSH Powder Bulk Supply – Product Specifications and COA.