Epithalon 50mg ZPHC: Laboratory-Grade Synthetic Tetrapeptide for Advanced Research

Product Overview

Epithalon (also known as Epitalon) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG), originally developed from the natural pineal gland polypeptide epithalamin . This laboratory-grade compound has been the subject of extensive scientific investigation into fundamental mechanisms of cellular aging, telomere maintenance, and circadian rhythm regulation .

This complete kit includes one hermetically sealed vial containing 50mg of lyophilized Epithalon powder and one vial of sterile bacteriostatic water for reconstitution. Each batch is batch-tracked and authenticity-verified, ensuring research integrity and reproducibility.

Key Research Applications

Telomerase Activity and Telomere Maintenance

Epithalon has been demonstrated to upregulate telomerase activity and promote telomere elongation in human somatic cell cultures . Research indicates that Epithalon can induce expression of the catalytic subunit of telomerase in telomerase-negative human fetal fibroblast cultures, suggesting potential for extending the replicative lifespan of cell populations .

Cellular Aging Models

Studies have shown that Epithalon treatment may delay age-related decline in physiological function. In research involving elderly subjects, treatment was associated with reduced mortality rates and decreased incidence of age-associated conditions including coronary artery disease, hypertension, osteoarthritis, and osteoporosis .

Circadian Rhythm and Pineal Function

Epithalon has been investigated for its regulatory effects on melatonin and cortisol production. Research in senescent animal models demonstrated that Epithalon significantly stimulates melatonin synthesis and normalizes circadian rhythm patterns .

Antioxidant Pathway Analysis

The peptide exhibits significant antioxidant properties and has been shown to influence gene expression related to oxidative stress responses . Research indicates potential for protecting against DNA damage through modulation of endogenous antioxidant defense systems .

Product Specifications

Quality Assurance

• Hermetically sealed sterile vials

• Batch-tracked and authenticity-verified

• Laboratory-grade material for research applications

• Complete kit includes sterile diluent for proper reconstitution

Reconstitution Protocol

1. Using sterile technique, add the supplied bacteriostatic water to the lyophilized powder vial

2. Gently swirl until fully dissolved – do not shake vigorously

3. Store reconstituted solution at 2-8°C and protect from light

4. For research use only – not for human consumption

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Frequently Asked Questions

1. What is Epithalon and how does it work?

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that has been researched for its ability to activate telomerase, the enzyme responsible for maintaining telomere length at chromosome ends . By upregulating telomerase activity, Epithalon may help preserve cellular integrity and delay senescence in cell populations . The peptide also influences gene expression, melatonin production, and antioxidant pathways .

2. What are the primary research applications for Epithalon?

Epithalon is primarily investigated in telomerase activity studies, cellular aging models, circadian rhythm research, and antioxidant pathway analysis . Research applications include longevity studies, sleep regulation investigations, and immune function research .

3. How should Epithalon be stored?

Lyophilized Epithalon powder should be stored in a cool, dry place, protected from direct light. After reconstitution with bacteriostatic water, the solution should be refrigerated at 2-8°C and protected from light exposure . For long-term storage of reconstituted material, adding a carrier protein such as 0.1% HSA or BSA is recommended .

4. What is the recommended reconstitution procedure?

Using sterile technique, add the supplied bacteriostatic water to the lyophilized powder vial. Gently swirl until fully dissolved – do not shake vigorously as this can damage the peptide structure. The reconstituted solution should be used promptly or stored at 2-8°C .

5. Is Epithalon safe for human use?

Epithalon has not received FDA approval and is not approved as a medicine outside limited contexts . While available clinical data suggest a favorable safety profile in research settings, the peptide is classified as a research chemical and is not intended for human consumption . Researchers should follow all standard laboratory safety protocols.

6. What do studies say about Epithalon and longevity?

Research has demonstrated that Epithalon may extend the replicative lifespan of cell populations and has been associated with reduced mortality in elderly study subjects . The peptide has been shown to increase lifespan in animal models including mice and fruit flies . However, robust human clinical trial data remains limited .

7. What is the significance of telomerase activation?

Telomerase is an enzyme that maintains telomere length at chromosome ends. As cells divide, telomeres naturally shorten, eventually triggering cellular senescence. Telomerase activation may preserve cellular replicative capacity and genomic stability . This mechanism is central to Epithalon’s research interest in aging studies.

8. How does Epithalon affect circadian rhythms?

Epithalon has been shown to stimulate melatonin synthesis in the pineal gland and normalize cortisol secretion patterns . Research in elderly subjects and animal models indicates that Epithalon may help restore disrupted circadian rhythms, with implications for sleep regulation and overall physiological homeostasis .

9. What are the theoretical risks associated with telomerase activation?

While telomerase activation may preserve healthy cell function, there is theoretical concern that it could support the survival of pre-malignant or malignant cells . No clinical link has been established in published human data, but researchers should be aware of this theoretical consideration in study design .

10. What quality control measures are in place for this product?

Each vial is hermetically sealed, sterile, batch-tracked, and authenticity-verified. The product is manufactured to laboratory-grade specifications for research applications. The complete kit includes sterile diluent for proper reconstitution .

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References and Further Reading

1. Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. PubMed

2. Khavinson VKh. et al. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.

3. Anisimov VN, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202.

For comprehensive information on peptide research, visit Peptides.org or consult the Alzheimer’s Drug Discovery Foundation for research context.

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For research use only. Not for human consumption. This product is not intended to diagnose, treat, cure, or prevent any disease. Researchers must comply with all applicable laws and institutional guidelines regarding peptide research.