Description

Buy Ultima-NAD+ 500 US

Ultima-NAD+ 500 is a research-grade product containing 500 mg of Nicotinamide Adenine Dinucleotide (NAD+), an essential coenzyme found in every living cell. NAD+ plays a critical role in numerous biological processes, including oxidative phosphorylation, adenosine triphosphate (ATP) production, DNA repair, calcium-dependent secondary messenger signaling, and gene expression . As a central regulator of cellular metabolism and energy production, NAD+ has become a molecule of intense scientific interest .

NAD+ is often described as a cell’s “fuel regulator,” helping the body produce energy, repair damaged DNA, and maintain proper cellular function . It is involved in key metabolic pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation by accepting and donating electrons . NAD+ also acts as a co-substrate for enzymes including sirtuins, poly (ADP-ribose) polymerases (PARPs), and CD38, which are involved in epigenetic regulation, DNA repair, and immune function .

The Scientific Context of NAD+

NAD+ levels naturally decline with age, and this fall is linked to memory loss, muscle weakness, and many age-related diseases . This decline has prompted researchers to investigate whether boosting NAD+ levels could help counteract age-related health decline and protect against diseases such as Alzheimer’s and Parkinson’s . An imbalance in the NAD+/NADH ratio caused by NAD+ depletion has been implicated in various conditions, including metabolic disease, aging, cancer, and cardiovascular diseases .

Scientific interest in NAD+ has grown substantially in recent years, with an expanding body of clinical research and trials. The journal Nature Aging published an expert opinion in 2025 consolidating evidence from over 25 international researchers, emphasizing the global effort to understand how NAD+ could be key to healthier aging . The authors highlight that while early results are encouraging, larger and longer-term clinical studies are needed to validate clinical efficacies and determine optimal dosing, long-term safety, and interindividual variability in response .

Mechanism of Action

NAD+ functions through two primary mechanisms :

1. Redox Cofactor: NAD+ facilitates metabolic pathways by accepting and donating electrons, supporting cellular energy production (ATP synthesis) and mitochondrial function. Lack of NAD+ in cells leads to mitochondrial dysfunction and increased reactive oxygen species (ROS) production .

2. Co-substrate for Consuming Enzymes: NAD+ is broken down into nicotinamide (NAM) and ADP-ribose, supporting enzymes involved in DNA repair (PARPs), epigenetic regulation (sirtuins), and immune function (CD38) .

Product Features

• 500 mg Unit Size: Research-grade concentration for laboratory protocols

• Pharmaceutical-Grade Quality: Manufactured to rigorous standards

• Lyophilized Format: Stable powder for reliable storage and reconstitution

• Versatile Application: Suitable for cellular metabolism, aging, and immune function research

Research Applications

Ultima-NAD+ 500 is suitable for laboratory research and preclinical studies in the following areas:

• Cellular Metabolism Research: Investigating energy production, mitochondrial function, and metabolic pathways

• Aging and Longevity Studies: Research on age-related decline and interventions targeting cellular health 

• DNA Repair and Epigenetics: Investigating PARP and sirtuin pathways

• Immune Function Research: Exploring NAD+ metabolism in macrophages and T cells, with implications for immune homeostasis, inflammation, and disease 

• Cardiovascular Research: Studying NAD+ depletion and supplementation in cardiovascular disease models 

Recommended Use

This product is intended solely for laboratory research purposes. The lyophilized powder must be reconstituted using sterile technique.

Reconstitution Instructions

1. Briefly centrifuge the vial before opening to bring contents to the bottom

2. Reconstitute in sterile distilled water or appropriate aqueous buffer to the desired concentration

3. Gently swirl until completely dissolved; do not vortex or shake vigorously

4. Apportion stock solutions into working aliquots for research protocols

Storage Instructions

• Lyophilized Powder: Store at -20°C to -70°C. Protect from light

• Do Not Freeze-Thaw Repeatedly: Avoid repeated freeze-thaw cycles

• After Reconstitution: Store at 2–8°C for short-term use, or at -20°C to -70°C for long-term storage

Research Use Disclaimer

This product is intended solely for laboratory research purposes. It is not suitable for human or animal consumption, nor for medical, veterinary, or household applications. Researchers should adhere to appropriate safety protocols and institutional guidelines.

Top 10 Frequently Asked Questions

1. What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in every cell of the body. It plays a central role in energy metabolism, ATP production, DNA repair, and gene expression .

2. Why is NAD+ of scientific interest?
NAD+ levels naturally decline with age, and this decline is linked to age-related health decline and diseases such as Alzheimer’s, Parkinson’s, metabolic disease, and cardiovascular disease . Researchers are investigating whether boosting NAD+ levels could support healthier aging and protect against these conditions.

3. What are the primary mechanisms of NAD+?
NAD+ functions as a redox cofactor in energy-producing pathways (glycolysis, TCA cycle, oxidative phosphorylation) and as a co-substrate for NAD+-consuming enzymes including sirtuins, PARPs, and CD38, which are involved in DNA repair, epigenetic regulation, and immune function .

4. What research applications is NAD+ suitable for?
NAD+ is used in cellular metabolism research, aging and longevity studies, DNA repair and epigenetics research, immune function studies, and cardiovascular research .

5. What do clinical trials show about NAD+?
A 2024 systematic review of 10 randomized clinical trials (489 participants) found NADH supplementation to be well tolerated with clinical results including decreased anxiety and maximum heart rate, increased muscle insulin sensitivity, and improvements in quality of life . However, experts emphasize the need for larger long-term studies to confirm clinical benefits .

6. What are the potential side effects observed in research?
The most common side effects reported in studies include muscle pain, nervous disorders, fatigue, sleep disturbance, and headaches. All adverse events cataloged did not present serious health risks to participants .

7. How does NAD+ relate to immune function?
NAD+ plays a significant role in regulation of immune cell function, particularly in macrophages and T cells. Research shows NAD+ facilitates metabolic reprogramming during immune cell differentiation and activation, with implications for autoimmune diseases and cancer .

8. How should NAD+ be stored?
Lyophilized powder should be stored at -20°C to -70°C. After reconstitution, store at 2–8°C for short-term use or at -20°C to -70°C for long-term storage. Avoid repeated freeze-thaw cycles.

9. What areas of research are currently exploring NAD+?
Current research includes aging and neurodegenerative diseases (Alzheimer’s, Parkinson’s), cardiovascular disease, metabolic health, and immune function . NAD+ precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are being studied in clinical trials .

10. Is NAD+ suitable for human use?
No. This product is intended solely for laboratory research purposes and is not suitable for human or animal consumption.

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