Description

Buy Ultima-HCG 10000 US

Ultima-HCG 10000 is a research-grade product containing 10,000 IU of Human Chorionic Gonadotropin. HCG is a glycoprotein hormone that is naturally produced by the developing placenta and plays a crucial role in various biological processes . In research and medical settings, it is valued for its ability to mimic the action of Luteinizing Hormone (LH), stimulating testosterone production in males and playing a key role in female fertility protocols . This 10,000 IU presentation is a standard high-concentration format often used in fertility and endocrine research .

Mechanism of Action

Human Chorionic Gonadotropin (hCG) is a natural analogue of Luteinizing Hormone (LH) and interacts with the same LH/hCG receptor . In males, this interaction stimulates the Leydig cells in the testes to produce testosterone, a process crucial for maintaining reproductive function and secondary sexual characteristics . For researchers studying the hypothalamic-pituitary-gonadal (HPG) axis, hCG serves as a valuable tool to investigate LH-mediated pathways and testicular function . The hormone is rapidly cleared from the body, with a detection window of up to 9 days following a single 10,000 IU injection, which is relevant for studies on excretion and metabolism .

Product Features

• High Potency: Delivers 10,000 IU of hCG per vial, a standard concentration for high-response protocols .

• Research-Grade Quality: Manufactured as a lyophilized powder for reliable storage and reconstitution.

• Mimics LH Activity: Acts as a potent agonist at the LH/hCG receptor, stimulating testosterone production .

• Versatile Application: Suitable for research into male hypogonadism, fertility, and testicular function .

Research Applications

Ultima-HCG 10000 is suitable for laboratory research and preclinical studies in the following areas:

• Male Reproductive Endocrinology: Investigating testosterone production, Leydig cell function, and spermatogenesis .

• Post-Cycle Therapy (PCT) Models: Studying the restoration of the HPG axis following suppression .

• Fertility Research: Examining ovulation, oocyte maturation, and corpus luteum formation .

• Pharmacokinetic Studies: Tracking hCG metabolism and clearance rates .

Recommended Use

This product is intended solely for laboratory research purposes. The lyophilized powder must be reconstituted with sterile water for injection before use.

Reconstitution Instructions

1. Clean the rubber stopper of the vial with an alcohol swab.

2. Draw the appropriate amount of sterile water (e.g., 1 mL or 10 mL depending on research protocol) into a sterile syringe .

3. Inject the water slowly against the glass wall of the vial to avoid foaming.

4. Gently swirl the vial to dissolve the powder; do not shake vigorously.

5. Ensure complete dissolution before drawing the solution for injection.

Research Dosing Considerations

In the research context, protocols vary significantly depending on the specific study.

• For HPG Axis Studies: Smaller, more frequent doses (e.g., 500–1,000 IU per day) are often employed to minimize estrogen-related side effects that can confound results .

• For Oocyte Maturation Studies: A single high dose of 5,000–10,000 IU is often used to trigger final oocyte maturation .

• For Pharmacokinetics: Research has utilized doses ranging from 5,000 to 30,000 IU to study urinary excretion and detection windows .

Storage Instructions

• Lyophilized Powder: Store unreconstituted vials in the refrigerator at 2–8°C. Protect from light and do not freeze .

• After Reconstitution: Use immediately or store as directed by institutional research protocols. For sterile use, refrigerate between doses and discard unused portions after a short period.

Side Effects

Research on hCG has documented potential effects in human subjects, which should be monitored in animal models and human clinical studies:

• Injection Site Reactions: Pain, redness, or swelling at the injection site .

• Hormonal Effects: Elevation of estrogen and testosterone levels, which may be relevant to research endpoints .

• Ovarian Hyperstimulation Syndrome (OHSS): In female fertility studies, a risk of OHSS exists, presenting as abdominal pain, bloating, and nausea .

• Other: Headache, mood swings, water retention, and gynecomastia in male subjects .

Contraindications

In clinical settings, hCG is contraindicated in individuals with:

• Known hypersensitivity to hCG or any of its components .

• Hormone-sensitive cancers (e.g., prostate or breast cancer) .

• Active thromboembolic disorders.

Top 10 Frequently Asked Questions

1. What is Ultima-HCG 10000?
Ultima-HCG 10000 is a research-grade product containing 10,000 IU of Human Chorionic Gonadotropin (hCG), a hormone that mimics Luteinizing Hormone (LH) and is used in endocrine and fertility research .

2. How does HCG work in the male body?
HCG interacts with the LH/hCG receptor on Leydig cells in the testes, stimulating them to produce testosterone, similar to the action of natural LH .

3. What is the mechanism of action of HCG?
HCG is a natural analogue of LH. It binds to the same receptor, initiating a cascade that leads to testosterone production in males and oocyte maturation in females .

4. What are the primary research applications for HCG?
It is used to study male hypogonadism, testicular function, ovulation, oocyte maturation, and the HPG axis .

5. What is the recommended reconstitution for the 10,000 IU vial?
It is typically reconstituted with 1 mL or 10 mL of sterile water. Using 1 mL creates a concentration of 10,000 IU/mL for a single dose, while 10 mL creates a 1,000 IU/mL concentration for easier measurement of multiple smaller doses .

6. How should HCG be stored?
Unreconstituted vials should be stored in the refrigerator at 2–8°C. After reconstitution, the solution should be refrigerated and used within the time frame defined by your research protocol .

7. What is the half-life or detection window of HCG?
In studies on males, a single 10,000 IU injection resulted in a urine detection window of up to 9 days, with peak urinary concentrations occurring within the first 12 hours .

8. Are there any side effects associated with HCG?
Potential side effects include injection site pain, fluid retention, gynecomastia, and in high-dose female fertility studies, Ovarian Hyperstimulation Syndrome (OHSS), which presents as abdominal pain and bloating .

9. Is HCG used in Post-Cycle Therapy (PCT)?
It is commonly studied in PCT models to reverse testicular atrophy and prepare the testes for recovery of natural testosterone production after the use of exogenous androgens .

10. What are the typical doses used in research?
Doses vary widely. Low-dose protocols for HPG axis studies often use 500–1,000 IU per day, while fertility research may use a single 5,000–10,000 IU injection. Pharmacokinetic studies have used doses as high as 30,000 IU .

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