Description

Buy Pharmaqo TB-500 (Thymosin Beta-4) 10mg

Pharmaqo TB-500 is a research-grade synthetic peptide derived from the naturally occurring protein thymosin beta-4 (Tβ4). Thymosin beta-4 is a 43-amino acid peptide found throughout human and animal tissues, where it plays a central role in wound healing, inflammation regulation, and tissue regeneration .

TB-500 is designed to mimic the active region (17LKKTETQ23) of thymosin beta-4, which is responsible for actin binding, cell migration, and wound healing . This 10 mg lyophilized formulation is intended for laboratory research applications investigating tissue repair and recovery mechanisms.

Mechanism of Action

TB-500’s primary sequence is the acetylated peptide LKKTETQ, matching the actin-binding domain of thymosin beta-4 .

Actin Binding and Cell Migration

The LKKTETQ sequence is responsible for actin binding and cellular motility . By influencing actin dynamics, TB-500 promotes cytoskeletal reorganization and cell migration speed, which are essential for cells to physically move into damaged areas during the repair process .

Angiogenesis and Vascular Support

TB-500 promotes endothelial cell differentiation and angiogenesis in dermal tissues . This supports the formation of new blood vessels to injury sites, improving oxygen and nutrient delivery to damaged tissues.

Anti-Inflammatory Effects

The peptide demonstrates potential in reducing inflammation by downregulating NF-κB, one of the major pathways driving chronic inflammation in joints and soft tissue injuries . TB-500 reduces the release of inflammatory mediators, creating an environment favorable for tissue repair.

Tissue Regeneration

TB-500 promotes keratinocyte migration, collagen deposition, and extracellular matrix remodeling . These processes are critical for wound closure and structural tissue repair.

Metabolite Activity

Recent research has revealed that the wound-healing activity of TB-500 may stem from one of its metabolites, Ac-LKKTE, rather than the parent compound itself . A 2024 study found that Ac-LKKTE showed significant wound healing activity compared to the control, suggesting that the way TB-500 is processed in the body matters as much as the peptide itself .

Product Features

• 10 mg Research Unit Size: Suitable for laboratory protocols

• >99% Purity by HPLC: Manufactured to rigorous research-grade standards 

• Lyophilized Format: Stable powder for reliable storage and reconstitution

• Acetylated Peptide: N-acetylated LKKTETQ sequence matching the active region of thymosin beta-4 

• Molecular Weight: 889.01 g/mol 

• Formula: C38H68N10O14 

• CAS Number: 885340-08-9 

Research Applications

This product is suitable for laboratory research and preclinical studies in the following areas:

• Tissue Repair and Regeneration Research: Studies on wound healing, angiogenesis, and cell migration mechanisms in muscle, tendon, ligament, and skin 

• Cytoskeletal Dynamics Research: Investigating actin binding, cell motility, and structural remodeling 

• Anti-Inflammatory Studies: Research on NF-κB pathway modulation and cytokine regulation 

• Musculoskeletal Recovery: Investigating mechanisms of muscle, tendon, and ligament healing 

• Angiogenesis Research: Studies on endothelial cell differentiation and vascular formation 

Recommended Use

This product is intended solely for laboratory research purposes. The lyophilized powder must be reconstituted using sterile technique.

Reconstitution Instructions

1. Briefly centrifuge the vial before opening to bring contents to the bottom

2. Reconstitute in sterile water (H₂O) to desired concentration. Solubility in water is 247.5 mg/mL (278.4 mM) with sonication recommended 

3. Gently swirl until completely dissolved; do not vortex or shake vigorously

4. Apportion stock solutions into working aliquots for research protocols

Storage Instructions

• Lyophilized Powder: Store at -20°C or below, dry, and protected from light. Keep away from moisture 

• In Solution: Prepare separate packages to avoid repeated freeze-thaw cycles

• Long-Term Stability: Keep lyophilized and frozen for extended shelf life

Regulatory and Research Status

• TB-500 is not FDA-approved for any therapeutic indication

• The World Anti-Doping Agency classifies thymosin beta-4 and its derivatives, including TB-500, as prohibited substances 

• Research shows TB-500 is a synthetic version of the naturally occurring peptide LKKTETQ, marketed for tissue repair and recovery applications 

• The peptide is intended for research and licensed medical use only, available under prescription in clinical settings 

Research Use Disclaimer

This product is intended solely for laboratory research purposes. It is not suitable for human or animal consumption, nor for medical, veterinary, or household applications. Researchers should adhere to appropriate safety protocols and institutional guidelines.

Top 10 Frequently Asked Questions

1. What is TB-500?
TB-500 is a synthetic peptide that corresponds to the active region (17LKKTETQ23) of the naturally occurring protein thymosin beta-4 . It is a 7-amino acid peptide with N-terminal acetylation .

2. How does TB-500 relate to thymosin beta-4?
TB-500 is a shorter, synthetic version of the active region of thymosin beta-4. It was developed as a more stable fragment that retains many of the protein’s biological effects, including actin binding, cell migration, and wound healing .

3. What is the molecular weight of TB-500?
The molecular weight is 889.01 g/mol .

4. What are the primary biological activities of TB-500?
TB-500 promotes endothelial cell differentiation, angiogenesis, keratinocyte migration, collagen deposition, and decreases inflammation .

5. What research applications is TB-500 used for?
It is used in tissue repair and regeneration research, cytoskeletal dynamics studies, anti-inflammatory investigations, and musculoskeletal recovery research .

6. What purity standards does Pharmaqo TB-500 meet?
Research-grade TB-500 is manufactured to >99% purity as determined by HPLC .

7. How should TB-500 be stored?
Lyophilized powder should be stored at -20°C or below, dry, and protected from light. Keep away from moisture .

8. What is the solubility of TB-500?
TB-500 is soluble in water at 247.5 mg/mL (278.4 mM). Sonication is recommended for optimal dissolution .

9. What does recent research show about TB-500 metabolites?
A 2024 study found that the metabolite Ac-LKKTE showed significant wound healing activity, suggesting that the previously reported wound-healing activity of TB-500 may be due to its metabolite rather than the parent compound .

10. Is TB-500 suitable for human use?
No. This product is intended solely for laboratory research purposes. It is not FDA-approved for any therapeutic indication and is classified as a prohibited substance by anti-doping agencies . In clinical settings, it is available only under prescription .

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