Description

Hubio Survodutide 10mg US

Hubio Survodutide is a research-grade dual agonist of the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R). This 10 mg lyophilized preparation is intended for laboratory research in metabolic and endocrine studies. Survodutide is a 29-amino-acid acylated peptide containing a C18 fatty acid for extended half-life, featuring a non-coded amino acid (1-aminocyclobutane-1-carboxylic acid) at position 2 for enhanced proteolytic stability .

In vitro studies have established the compound’s potency: Survodutide exhibits EC₅₀ values of 0.52 nM at GCGR and 0.33 nM at GLP-1R in CHO-K1 cells . This balanced potency profile is crucial for achieving therapeutic effects while minimizing hyperglycemic risk . The compound is currently in Phase 3 clinical development (SYNCHRONIZE trials) for the treatment of obesity and metabolic diseases .

Mechanism of Action

Survodutide’s dual receptor activation profile drives body weight reduction through two complementary mechanisms:

1. GLP-1R Activation: Suppresses appetite via central nervous system pathways .

2. GCGR Activation: Increases energy expenditure .

Preclinical research suggests that the satiety effects are primarily GLP-1R dependent . The compound activates neuronal regions associated with appetite regulation without uniformly crossing the blood-brain barrier, instead acting through circumventricular organs .

Product Features

• 10 mg Research Unit Size: Suitable for laboratory protocols

• ≥99% Purity: Manufactured to rigorous standards 

• Lyophilized Format: Stable powder for reliable reconstitution

• 29-Amino Acid Peptide: With C18 fatty acid for extended half-life 

Research Applications

This product is suitable for laboratory research and preclinical studies in the following areas:

• GLP-1/Glucagon Receptor Dual Agonist Pathway Research: Investigating signaling mechanisms and metabolic effects.

• Obesity and Metabolic Research: Evaluating effects on energy balance, appetite regulation, and lipid metabolism.

• Glycemic Control Studies: Research on glucose homeostasis and insulin sensitivity.

• Metabolic Dysfunction-Associated Steatohepatitis (MASH) Research: Investigating liver fat accumulation and fibrosis reduction .

Clinical Research Context

Phase 2 clinical trial data for Survodutide reported the following outcomes in adults with obesity, which serve as context for research applications:

• Weight Reduction: −6.2% (0.6 mg), −12.5% (2.4 mg), −13.2% (3.6 mg), −14.9% (4.8 mg) vs. −2.8% with placebo at 46 weeks . A separate review reported up to 18.7% weight loss at higher doses .

• Glycemic Control: HbA1c reductions of up to −1.71% .

• Blood Pressure: Significant reductions in both systolic and diastolic blood pressure .

• Pharmacodynamics: A post-hoc meta-analysis of Phase 2 trials reported the following mean changes from baseline :

• Safety: Gastrointestinal adverse events (nausea, vomiting, diarrhea) were common and predominantly mild-to-moderate in severity . Preclinical cardiac studies have shown positive chronotropic (heart rate) and inotropic (contractile force) effects, which are believed to be mediated through GCGR and GLP-1R pathways .

Recommended Use

This product is intended solely for laboratory research purposes. The lyophilized powder must be reconstituted using sterile technique.

Reconstitution Instructions

1. Briefly centrifuge the vial before opening to bring contents to the bottom.

2. Reconstitute in sterile distilled water or appropriate aqueous buffer.

3. Gently swirl until completely dissolved; do not vortex or shake vigorously.

4. Apportion stock solutions into working aliquots for research protocols.

Storage Instructions

• Lyophilized Powder: Store at −20°C to −80°C. Protect from light and moisture.

• In Solution: Store at −80°C for up to 6 months or at −20°C for up to 1 month .

• Avoid Repeated Freeze-Thaw Cycles: Aliquot stock solutions to prevent product inactivation.

Research Use Disclaimer

This product is intended solely for laboratory research purposes. It is not suitable for human or animal consumption, nor for medical, veterinary, or household applications. Researchers should adhere to appropriate safety protocols and institutional guidelines.

Top 10 Frequently Asked Questions

1. What is Survodutide?
Survodutide (BI 456906) is a research-grade dual agonist of the glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R). This 10 mg preparation is intended for laboratory research in metabolic studies.

2. What is the mechanism of action of Survodutide?
It activates both GCGR and GLP-1R. GLP-1R activation reduces appetite, while GCGR activation increases energy expenditure .

3. What are the potencies of Survodutide?
In CHO-K1 cells, EC50 values are 0.52 nM for GCGR and 0.33 nM for GLP-1R .

4. What clinical trial evidence supports Survodutide?
Phase 2 trials have demonstrated weight loss up to 18.7% and HbA1c reductions up to −1.71%, with Phase 3 SYNCHRONIZE trials currently ongoing .

5. What dose strengths have been studied in clinical trials?
Clinical trials have studied survodutide at 0.6 mg, 2.4 mg, 3.6 mg, 4.8 mg, and up to 6.0 mg once-weekly doses .

6. What are the most common side effects observed?
Gastrointestinal adverse events including nausea, vomiting, and diarrhea were most common and predominantly mild-to-moderate in severity .

7. What metabolic benefits beyond weight loss have been observed?
Significant reductions in waist circumference, systolic and diastolic blood pressure, and HbA1c have been reported .

8. What is the molecular identity of Survodutide?
It is a 29-amino-acid acylated peptide featuring a C18 fatty acid, with a non-coded amino acid (1-aminocyclobutane-1-carboxylic acid) at position 2 .

9. How should this product be stored?
Lyophilized powder should be stored at −20°C to −80°C, protected from light and moisture. After reconstitution, store at −80°C for up to 6 months and avoid repeated freeze-thaw cycles .

10. Is Hubio Survodutide suitable for human use?
No. This product is intended solely for laboratory research purposes and is not suitable for human or animal consumption.

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